Top 5 U.S. Stocks With Explosive Gains and Heavy Trading Volume in the Last 24 Hours September 2025 Update
On September 2, 2025, Wall Street witnessed an electrifying trading session. Several U.S. stocks delivered massive double- and even triple-digit percentage gains backed by record-breaking volumes. From penny-stock rockets to biotech breakouts, this article highlights the top five U.S. equities that combined exceptional momentum with strong liquidity.
Quick Overview: Top 5 Daily Gainers by Growth and Volume
| Rank | Stock (Ticker) | Gain % | Volume (Approx.) | Sector |
|---|---|---|---|---|
| 1 | HWH International (HWH) | +227.78% | 323M shares | Consumer Services |
| 2 | Carisma Therapeutics (CARM) | +104.65% | 375M shares | Biotechnology |
| 3 | Mineralys Therapeutics (MLYS) | +86.43% | 15.7M shares | Biotechnology |
| 4 | Sound Group Inc. (SOGP) | +82.40% | 18.6M shares | Technology/Media |
| 5 | Universal Safety Products (UUU) | +75.15% | 65.3M shares | Industrial Safety |
Why HWH International Dominated the Market
HWH International (HWH) delivered the most spectacular surge of the session, skyrocketing 227.78% with 323 million shares traded. This combination of huge price action and massive liquidity placed HWH at the top of both gainers and most-active lists. Speculative retail interest and potential corporate updates may have driven the spike.
Carisma Therapeutics: A Biotech Breakout
Carisma Therapeutics (CARM) more than doubled in value, climbing 104.65% with an extraordinary 375 million shares traded. The move suggests investors were reacting to biotech-related developments, such as pipeline updates or market speculation around partnerships and clinical advancements.
Mineralys Therapeutics: A Rising Biotech Star
Mineralys Therapeutics (MLYS) gained 86.43%, supported by a robust 15.7 million shares traded. While smaller in volume compared to penny-stock rockets, this move is significant in the biotech sector, where clinical trial progress or FDA news often sparks dramatic price swings.
Sound Group Inc.: Riding the Momentum Wave
Sound Group Inc. (SOGP) jumped 82.40% with nearly 18.6 million shares exchanged. As a technology and media player, the stock’s surge may have been fueled by momentum traders and speculative demand, making it one of the hottest names in mid-cap trading circles.
Universal Safety Products: Industrial Surge
Universal Safety Products (UUU) climbed 75.15%, driven by 65.27 million shares traded. This demonstrates both strong liquidity and volatility. While not as speculative as penny stocks, UUU’s rally highlights investor appetite for industrial safety and equipment sectors.
What’s Driving These Moves?
- Speculative Trading & Retail Buzz: Many top movers—HWH, CARM, and UUU—are small-cap or penny stocks that thrive on momentum and social media hype.
- Biotech Catalysts: Both MLYS and CARM surged on sector-specific developments, as biotech remains one of the most volatile yet rewarding markets.
- Liquidity Meets Volatility: High volumes in SOGP and others signal strong demand but also heightened risk for short-term traders.
Investor Takeaways
For investors and traders, these explosive gains offer both opportunity and caution:
- Short-term traders may find opportunities in momentum-driven stocks but should apply strict risk controls.
- Long-term investors should analyze fundamentals rather than chasing daily spikes.
- Volume trends help determine whether moves are sustainable or just speculative bursts.
- Price corrections are common after triple-digit rallies, making timing crucial.
References & Sources
- StockAnalysis.com – Top Gainers
- Barchart.com – Most Active Stocks
- Investing.com – Stock Gainers
- Morningstar – Market Movers
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